Choi, HyunokMc Auley, Mark T.Lawrence, David A.2015-03-242015-03-242015-02-19Choi, H., Mc Auley, M. T., & Lawrence, D. A. (2015). Prenatal exposures and exposomics of asthma. AIMS Environmental Science, 2(1), 87-109.10.3934/environsci.2015.1.87http://hdl.handle.net/10034/347044This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental mediaen-USasthmamathematical modellingArticleAIMS Environmental Science