Rajadorai, SindhujaHarris, GenevieveRobinson, AlistairMiles, Emma J.Roberts, JonathanCooper, LeeAbou Neel, Ensanya A.Higham, Susan M.Flannigan, Norah LValappil, Sabeel P.2023-02-022023-02-022021-09-11Rajadorai, S., Harris, G., Robinson, A., Miles, E. J., Roberts, J. M., Cooper, L., Abou Neel, E.A., Higham, SM., Flannigan N.L., & Valappil, S. P. (2022). Antibacterial, remineralising zinc oxide-doped phosphate-based glasses. Materials Letters. 306, 130813. https://doi.org/10.1016/j.matlet.2021.1308130167-577X10.1016/j.matlet.2021.130813http://hdl.handle.net/10034/627503This study reports a novel melt quenched zinc oxide-doped phosphate-based glasses (Zn-PBGs) of varying CaO mol% designated as C11, C12, C13. The glass degradation rate, ions release, antibacterial activity against S. mutans and remineralization potential were investigated. Zn-PBGs showed one order of magnitude higher degradation rate than Zn-free PBG. The highest rate was observed for C11; Na+, Ca2+, Zn2+ and P5+ release followed the same trend. The higher the Zn2+ release, the greater the S. mutans growth inhibition. C11 showed significantly lower mineral loss from enamel than positive and negative controls. Zn-PBGs could be used to reverse enamel demineralization.https://creativecommons.org/licenses/by-nc-nd/4.0/BiomaterialsMicrobiologyArticleMaterials Letters