Burke, TomRodriguez-Santana, IdairaChowdary, PratimaCurtis, RandallKhair, KateLaffan, MichaelMcLaughlin, PaulNoone, DeclanO'Mahony, BrianPasi, JohnSkinner, Mark W.O'Hara, Jamie2022-12-272022-12-272022-12-27Burke, T., Rodriguez‐Santana, I., Chowdary, P., Curtis, R., Khair, K., Laffan, M., McLaughlin, P., Noone, D., O'Mahony, B., Pasi, J., Skinner, M., & O'Hara, J. (2022). Humanistic burden of problem joints for children and adults with haemophilia. Haemophilia, 29(2), 608-618. https://doi.org/10.1111/hae.147311351-821610.1111/hae.14731http://hdl.handle.net/10034/627400Introduction: The “problem joint” (PJ) concept was developed to address patient‐centric needs for a more holistic assessment of joint morbidity for people with haemophilia (PwH). Aim: To quantify the humanistic burden of PJs in PwH to further support validation of the PJ outcome measure. Methods: Multivariable regression models evaluated the relationship between PJs and health‐related quality of life (HRQoL, EQ‐5D‐5L) and overall work productivity loss (WPL) using data from the ‘Cost of HaEmophilia: a Socioeconomic Survey’ population studies (adults: CHESS II, CHESS US+; children/adolescents: CHESS‐Paeds). Covariates included were haemophilia severity, age, comorbidities and education. Results: The CHESS II sample included 292 and 134 PwH for HRQoL and WPL analyses, mean age 38.6 years (39% ≥1 PJ, 61% none). CHESS US+ included 345 and 239 PwH for HRQoL and WPL, mean age 35 years (43% ≥1 PJ, 57% none). CHESS‐Paeds included 198 PwH aged 4–17 (HRQoL only), mean age 11.5 years (19% ≥1 PJ, 81% none). In CHESS II and CHESS US+, presence of PJs was associated with worse HRQoL (Both p < .001). Few CHESS‐Paeds participants had PJs, with no significant correlation with HRQoL. In CHESS II, upper body PJs were significantly correlated to WPL (p < .05). In CHESS US+, having ≥1 PJ or upper and lower body PJs were significantly correlated to WPL (vs. none; both p < .05). Conclusion: This study has shown a meaningful burden of PJs on PwH, which should be considered in clinical and health policy assessments of joint health.Licence for VoR version of this article: http://creativecommons.org/licenses/by-nc-nd/4.0/https://creativecommons.org/licenses/by-nc-nd/4.0/HaemarthrosisHaemophiliaJointsChildrenArticleHaemophilia2022-12-2729