Hazell, GavinArnold, ThomasTognoloni, CeciliaBarker, RobertClifton, LukeSteinke, Nina-JulianeEdler, Karen2019-06-282019-06-282016-10-14Hazell, G., Arnold, T., Barker, R., Clifton, L., Steinke, N., Tognoloni, C., & Edler, K. (2016). Evidence of lipid exchange in styrene maleic acid lipid particle (SMALP) nanodisc systems. Langmuir, 32(45), 11845-118530743-746310.1021/acs.langmuir.6b02927http://hdl.handle.net/10034/622384This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.6b02927Styrene-alt-maleic Acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs, including the potential to control lipid composition within nanodiscs containing membrane proteinsenhttp://creativecommons.org/licenses/by-nc-nd/4.0/Article1520-5827Langmuir