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The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival.
Valpione, Sara Mundra, Piyushkumar A Galvani, Elena Campana, Luca G; orcid: 0000-0002-8466-8459 Lorigan, Paul; orcid: 0000-0002-8875-2164 De Rosa, Francesco; orcid: 0000-0003-0511-1298 Gupta, Avinash Weightman, John Mills, Sarah Dhomen, Nathalie
Valpione, Sara
Mundra, Piyushkumar A
Galvani, Elena
Campana, Luca G; orcid: 0000-0002-8466-8459
Lorigan, Paul; orcid: 0000-0002-8875-2164
De Rosa, Francesco; orcid: 0000-0003-0511-1298
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
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2021-07-02
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Abstract
Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
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Nature communications, volume 12, issue 1, page 4098
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From Europe PMC via Jisc Publications Router
History: ppub 2021-07-01, epub 2021-07-02
Publication status: Published
Funder: Wellcome Trust; Grant(s): 100282/Z/12/Z
Funder: Cancer Research UK; Grant(s): A22902, A27412
History: ppub 2021-07-01, epub 2021-07-02
Publication status: Published
Funder: Wellcome Trust; Grant(s): 100282/Z/12/Z
Funder: Cancer Research UK; Grant(s): A22902, A27412