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The efficacy of Ketamine for acute and chronic pain in patients with cancer: A systematic review of randomized controlled trials
Azari, Leila Hemati, Homa Tavasolian, Ronia Shahdab, Sareh Tomlinson, Stephanie M. Bobonis Babilonia, Margarita Huang, Jeffrey Tometich, Danielle B. Turner, Kea Saleh Anaraki, Kimia
Azari, Leila
Hemati, Homa
Tavasolian, Ronia
Shahdab, Sareh
Tomlinson, Stephanie M.
Bobonis Babilonia, Margarita
Huang, Jeffrey
Tometich, Danielle B.
Turner, Kea
Saleh Anaraki, Kimia
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EPub Date
Publication Date
2024-08-06
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Abstract
Managing cancer-related pain poses significant challenges, prompting research into alternative approaches such as ketamine. This systematic review aims to analyze and summarize the impact of ketamine as an adjuvant to opioid therapy for cancer-related pain. We conducted a literature review in MEDLINE, EMBASE, and Scopus from 1 January 1982 to 20 October 2023. Abstracts were screened against inclusion criteria, and eligible studies underwent a full-text review. Data was extracted from the included studies, and a framework analysis approach summarized the evidence regarding ketamine’s use in patients with cancer. A total of 21 randomized clinical trials were included, and the quality of all the included studies was good or fair. Significant improvements in pain scores and reduced morphine consumption were consistently observed with intravenous ketamine administration for postoperative pain control, particularly when combined with other analgesics such as morphine. Ketamine was less effective when used as an analgesic for chronic pain management, with several studies on neuropathic pain or chemotherapy-induced neuropathy finding minimal significant effect on reduction of pain scores or morphine requirements. The efficacy of ketamine in pain management appears to depend on factors such as dosage, route of administration, and patient population.
Citation
Azari, L., Hemati, H., Tavasolian, R., Shahdab, S., Tomlinson, S. M., Bobonis Babilonia, M., Huang, J., Tometich, D. B., Turner, K., Saleh Anaraki, K., Jim, H. S. L., & Alishahi Tabriz, A. (2024). The efficacy of Ketamine for acute and chronic pain in patients with cancer: A systematic review of randomized controlled trials. Healthcare, 12(16), 1560. https://doi.org/10.3390/healthcare12161560
Publisher
MDPI
Journal
Healthcare
Research Unit
DOI
10.3390/healthcare12161560
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Article
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
A correction to this article has been published which can be accessed via this DOI: 10.3390/healthcare12222219
A correction to this article has been published which can be accessed via this DOI: 10.3390/healthcare12222219
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ISSN
EISSN
2227-9032
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Unfunded