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Dissolving microneedle system containing Ag nanoparticle-decorated silk fibroin microspheres and antibiotics for synergistic therapy of bacterial biofilm infection
Li, Yao Gong, Jue-Ying Wang, Po Fu, Han Faraj, Yousef Xie, Rui Wang, Wei Liu, Zhuang Pan, Da-Wei Ju, Xiao-Jie
Li, Yao
Gong, Jue-Ying
Wang, Po
Fu, Han
Faraj, Yousef
Xie, Rui
Wang, Wei
Liu, Zhuang
Pan, Da-Wei
Ju, Xiao-Jie
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Publication Date
2024-01-26
Submitted Date
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Abstract
Most cases of delayed wound healing are associated with bacterial biofilm infections due to high antibiotic resistance. To improve patient compliance and recovery rates, it is critical to develop minimally invasive and efficient methods to eliminate bacterial biofilms as an alternative to clinical debridement techniques. Herein, we develop a dissolving microneedle system containing Ag nanoparticles (AgNPs)-decorated silk fibroin microspheres (SFM-AgNPs) and antibiotics for synergistic treatment of bacterial biofilm infection. Silk fibroin microspheres (SFM) are controllably prepared in an incompatible system formed by a mixture of protein and carbohydrate solutions by using a mild all-aqueous phase method and serve as biological templates for the synthesis of AgNPs. The SFM-AgNPs exert dose- and time-dependent broad-spectrum antibacterial effects by inducing bacterial adhesion. The combination of SFM-AgNPs with antibiotics breaks the limitation of the antibacterial spectrum and achieves better efficacy with reduced antibiotic dosage. Using hyaluronic acid (HA) as the soluble matrix, the microneedle system containing SFM-AgNPs and anti-Gram-positive coccus drug (Mupirocin) inserts into the bacterial biofilms with sufficient strength, thereby effectively delivering the antibacterial agents and realizing good antibiofilm effect on Staphylococcus aureus-infected wounds. This work demonstrates the great potential for the development of novel therapeutic systems for eradicating bacterial biofilm infections.
Citation
Li, Y., Gong, J-Y., Wang, P., Fu, H., Faraj, Y., Xie, R., Wang, W., Liu, Z., Pan, D-W., Ju, X-J., & Chu, L-Y. (2024). Dissolving microneedle system containing Ag nanoparticle-decorated silk fibroin microspheres and antibiotics for synergistic therapy of bacterial biofilm infection. Journal of Colloid and Interface Science, 661, 123-138. https://doi.org/10.1016/j.jcis.2024.01.147
Publisher
Elsevier
Journal
Journal of Colloid and Interface Science
Research Unit
DOI
10.1016/j.jcis.2024.01.147
PubMed ID
PubMed Central ID
Type
Article
Language
Description
Series/Report no.
ISSN
0021-9797
EISSN
1095-7103