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Bioinspired bactericidal surfaces with polymer nanocone arrays
Hazell, Gavin Fisher, Leanne E. Murray, Andrew W. Nobbs, Angela H. Su, Bo
Hazell, Gavin
Fisher, Leanne E.
Murray, Andrew W.
Nobbs, Angela H.
Su, Bo
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Other Contributors
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EPub Date
Publication Date
2018-05-28
Submitted Date
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Adobe PDF, 1.76 MB
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Abstract
Infections resulting from bacterial biofilm formation on the surface of medical devices are challenging to treat and can cause significant patient morbidity. Recently, it has become apparent that regulation of surface nanotopography can render surfaces bactericidal. In this study, poly(ethylene terephthalate) nanocone arrays are generated through a polystyrene nanosphere-mask colloidal lithographic process. It is shown that modification of the mask diameter leads to a direct modification of centre-to-centre spacing between nanocones. By altering the oxygen plasma etching time it is possible to modify the height, tip width and base diameter of the individual nanocone features. The bactericidal activity of the nanocone arrays was investigated against Escherichia coli and Klebsiella pneumoniae. It is shown that surfaces with the most densely populated nanocone arrays (center-to-center spacing of 200 nm), higher aspect ratios (>3) and tip widths <20 nm kill the highest percentage of bacteria (∼30%).
Citation
Hazell, G., et al (2018). Bioinspired bactericidal surfaces with polymer nanocone arrays. Journal of Colloid and Interface Science, 528, 389-399. https://doi.org/10.1016/j.jcis.2018.05.096
Publisher
Elsevier
Journal
Journal of Colloid and Interface Science
Research Unit
DOI
10.1016/j.jcis.2018.05.096
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
1095-7103