Correspondence of continuous interstitial glucose measurement against arterialised and capillary glucose following an oral glucose tolerance test in healthy volunteers
Dye, Louise Mansfield, Michael Lasikiewicz, Nicola Mahawish, Lena Schnell, Rainer Talbot, Duncan Chauhan, Hitesh Croden, Fiona Lawton, Clare
Dye, Louise
Mansfield, Michael
Lasikiewicz, Nicola
Mahawish, Lena
Schnell, Rainer
Talbot, Duncan
Chauhan, Hitesh
Croden, Fiona
Lawton, Clare
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Publication Date
2009-08-13
Submitted Date
Collections
Other Titles
Abstract
The aim of the present study was to validate the Glucodayw continuous interstitial ambulatory glucose-monitoring device (AGD) against plasma
glucose measured from arterialised venous (AV) and glucose from capillary whole blood (finger prick, FP) in non-diabetic subjects in response to
an oral glucose tolerance test. Fifteen healthy overweight men (age 30–49 years, BMI 26–31 kg/m2
) participated. Glucose levels were measured
before, during and after consumption of an oral 75 g glucose load using twelve FP samples and forty-four 1 ml AV blood samples during 180 min.
Interstitial glucose was measured via the AGD. Three venous samples for fasting insulin were taken to estimate insulin resistance. Profiles of AGD,
AV and FP glucose were generated for each participant. Glucose values for each minute of the measurement period were interpolated using a
locally weighted scatterplot smoother. Data were compared using Bland–Altman plots that showed good correspondence between all pairs of
measurements. Concordance between the three methods was 0·8771 (Kendall’s W, n 15, P,0·001). Concordance was greater between AV
and FP (W ¼ 0·9696) than AGD and AV (W ¼ 0·8770) or AGD and FP (W ¼ 0·8764). Analysis of time to peak glucose indicated that AGD
measures lagged approximately 15 min behind FP and AV measures. Percent body fat was significantly correlated with time to peak glucose
levels for each measure, while BMI and estimated insulin resistance (homeostatic model assessment, HOMA) were not. In conclusion, AGD
shows good correspondence with FP and AV glucose measures in response to a glucose load with a 15 min time lag. Taking this into account,
AGD has potential application in nutrition and behaviour studies.
Citation
Lasikiewicz, N. et al (2010) Correspondence of continuous interstitial glucose measurement against arterialised and capillary glucose following an oral glucose tolerance test in healthy volunteers. British Journal of Nutrition, 103(01):134
Publisher
Journal
British Journal of Nutrition
Research Unit
DOI
10.1017/S0007114509991504
PubMed ID
PubMed Central ID
Type
Article
Language
Description
Series/Report no.
ISSN
0007-1145
1475-2662
1475-2662