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A bio-assay for effectors of osteoclast differentiation in serum from patients with bone disease

Dugard, Marit-Naomi
; 
Sharp, Christopher A.
; 
Evans, Sally F.
; 
Williams, John H. H.
; 
Davie, Michael W. J.
; 
Marshall, Michael J.
Advisors
Editors
Other Contributors
Affiliation
Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; University of Chester ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry
EPub Date
Publication Date
2005-06
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Biological Sciences
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Abstract
Osteoclast differentiation and activity, and hence bone loss, depend on two opposing cytokines. Receptor activator of NF-κB ligand (RANKL) produced by osteoblasts and T-cells stimulates, while osteoprotegerin inhibits. Both of these cytokines are found in serum. Our aim was to develop a functional assay for any factors present in human serum that can affect osteoclast differentiation and to assess whether any such factors vary in diseases in which bone loss occurs.
Citation
Clinica Chimica Acta, 356(1-2), (2005), pp. 154-163.
Publisher
Elsevier
Journal
Clinica Chimica Acta
Research Unit
URI
http://hdl.handle.net/10034/67764
DOI
10.1016/j.cccn.2005.01.020
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
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ISSN
0009-8981
EISSN
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http://www.elsevier.com/wps/find/journaldescription.cws_home/506018/description#description