Loading...
Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis
Ersoy, Ufuk Kanakis, Ioannis Alameddine, Moussira Pedraza-Vazquez, Gibran Ozanne, Susan E. Peffers, Mandy J. Jackson, Malcolm J. Goljanek-Whysall, Katarzyna Vasilaki, Aphrodite
Ersoy, Ufuk
Kanakis, Ioannis
Alameddine, Moussira
Pedraza-Vazquez, Gibran
Ozanne, Susan E.
Peffers, Mandy J.
Jackson, Malcolm J.
Goljanek-Whysall, Katarzyna
Vasilaki, Aphrodite
Advisors
Editors
Other Contributors
EPub Date
Publication Date
2023-12-02
Submitted Date
Collections
Files
Loading...
Article - VoR
Adobe PDF, 12.47 MB
Other Titles
Abstract
The early life environment significantly affects the development of age-related skeletal muscle disorders. However, the long-term effects of lactational protein restriction on skeletal muscle are still poorly defined. Our study revealed that male mice nursed by dams fed a low-protein diet during lactation exhibited skeletal muscle growth restriction. This was associated with a dysregulation in the expression levels of genes related to the ribosome, mitochondria and skeletal muscle development. We reported that lifelong protein restriction accelerated loss of type-IIa muscle fibres and reduced muscle fibre size by impairing mitochondrial homeostasis and proteostasis at 18 months of age. However, feeding a normal-protein diet following lactational protein restriction prevented accelerated fibre loss and fibre size reduction in later life. These findings provide novel insight into the mechanisms by which lactational protein restriction hinders skeletal muscle growth and includes evidence that lifelong dietary protein restriction accelerated skeletal muscle loss in later life.
Citation
Ersoy, U., Kanakis, I., Alameddine, M., Pedraza Vazquez, G., E. Ozanne, S., Peffers, M. J., Jackson, M.J., Goljanek-Whysall, K. & Vasilaki, A. (2023). Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis. Redox Biology, 69, article-number 102980. https://doi.org/10.1016/j.redox.2023.102980.
Publisher
Elsevier
Journal
Redox Biology
Research Unit
DOI
10.1016/j.redox.2023.102980
PubMed ID
PubMed Central ID
Type
Article
Language
Description
© 2023 The Authors. Published by Elsevier B.V.
Series/Report no.
ISSN
EISSN
2213-2317