Loading...
The LEGATOS technique: A new tissue‐validated dynamic contrast‐enhanced MRI method for whole‐brain, high‐spatial resolution parametric mapping
Li, Ka‐Loh; orcid: 0000-0002-6051-9248; email: ka-loh.li-2@manchester.ac.uk Lewis, Daniel Coope, David J. Roncaroli, Federico Agushi, Erjon Pathmanaban, Omar N. King, Andrew T. Zhao, Sha Jackson, Alan Cootes, Timothy
Li, Ka‐Loh; orcid: 0000-0002-6051-9248; email: ka-loh.li-2@manchester.ac.uk
Lewis, Daniel
Coope, David J.
Roncaroli, Federico
Agushi, Erjon
Pathmanaban, Omar N.
King, Andrew T.
Zhao, Sha
Jackson, Alan
Cootes, Timothy
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Publication Date
2021-05-15
Submitted Date
2020-06-30
Collections
Files
Other Titles
Abstract
Purpose: A DCE‐MRI technique that can provide both high spatiotemporal resolution and whole‐brain coverage for quantitative microvascular analysis is highly desirable but currently challenging to achieve. In this study, we sought to develop and validate a novel dual‐temporal resolution (DTR) DCE‐MRI‐based methodology for deriving accurate, whole‐brain high‐spatial resolution microvascular parameters. Methods: Dual injection DTR DCE‐MRI was performed and composite high‐temporal and high‐spatial resolution tissue gadolinium‐based‐contrast agent (GBCA) concentration curves were constructed. The high‐temporal but low‐spatial resolution first‐pass GBCA concentration curves were then reconstructed pixel‐by‐pixel to higher spatial resolution using a process we call LEGATOS. The accuracy of kinetic parameters (Ktrans, vp, and ve) derived using LEGATOS was evaluated through simulations and in vivo studies in 17 patients with vestibular schwannoma (VS) and 13 patients with glioblastoma (GBM). Tissue from 15 tumors (VS) was examined with markers for microvessels (CD31) and cell density (hematoxylin and eosin [H&E]). Results: LEGATOS derived parameter maps offered superior spatial resolution and improved parameter accuracy compared to the use of high‐temporal resolution data alone, provided superior discrimination of plasma volume and vascular leakage effects compared to other high‐spatial resolution approaches, and correlated with tissue markers of vascularity (P ≤ 0.003) and cell density (P ≤ 0.006). Conclusion: The LEGATOS method can be used to generate accurate, high‐spatial resolution microvascular parameter estimates from DCE‐MRI.
Citation
Magnetic Resonance in Medicine
Publisher
Journal
Research Unit
DOI
PubMed ID
PubMed Central ID
Type
article
Language
Description
From Wiley via Jisc Publications Router
History: received 2020-06-30, rev-recd 2021-04-23, accepted 2021-04-24, pub-electronic 2021-05-15
Article version: VoR
Publication status: Published
Funder: Dowager Countess Eleanor Peel Trust; Id: http://dx.doi.org/10.13039/501100000832
Funder: Cancer Research UK; Id: http://dx.doi.org/10.13039/501100000289; Grant(s): C8742/A18097
History: received 2020-06-30, rev-recd 2021-04-23, accepted 2021-04-24, pub-electronic 2021-05-15
Article version: VoR
Publication status: Published
Funder: Dowager Countess Eleanor Peel Trust; Id: http://dx.doi.org/10.13039/501100000832
Funder: Cancer Research UK; Id: http://dx.doi.org/10.13039/501100000289; Grant(s): C8742/A18097