Loading...
Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity
Halevas, Eleftherios Mavroidi, Barbara Nday, Christiane Tang, Jianhua Smith, Graham Boukos, Nikos Litsardakis, George Pelecanou, Maria Salifoglou, Athanasios
Halevas, Eleftherios
Mavroidi, Barbara
Nday, Christiane
Tang, Jianhua
Smith, Graham
Boukos, Nikos
Litsardakis, George
Pelecanou, Maria
Salifoglou, Athanasios
Advisors
Editors
Other Contributors
EPub Date
Publication Date
2020-10-06
Submitted Date
Collections
Files
Loading...
Main article
Adobe PDF, 1.06 MB
Other Titles
Abstract
Targeted tissue drug delivery is a challenge in contemporary nanotechnologically driven therapeutic approaches, with the interplay interactions between nanohost and encapsulated drug shaping the ultimate properties of transport, release and efficacy of the drug at its destination. Prompted by the need to pursue the synthesis of such hybrid systems, a family of modified magnetic core-shell mesoporous silica nano-formulations was synthesized with encapsulated quercetin, a natural flavonoid with proven bioactivity. The new nanocarriers were produced via the sol-gel process, using tetraethoxysilane as a precursor and bearing a magnetic core of surface-modified monodispersed magnetite colloidal superparamagnetic nanoparticles, subsequently surface-modified with polyethylene glycol 3000 (PEG3k). The arising nano-formulations were evaluated for their textural and structural properties, exhibiting enhanced solubility and stability in physiological media, as evidenced by the loading capacity, entrapment efficiency results and in vitro release studies of their load. Guided by the increased bioavailability of quercetin in its encapsulated form, further evaluation of the biological activity of the magnetic as well as non-magnetic core-shell nanoparticles, pertaining to their anti-amyloid and antioxidant potential, revealed interference with the aggregation of β-amyloid peptide (Aβ) in Alzheimer’s disease, reduction of Aβ cellular toxicity and minimization of Aβ-induced Reactive Oxygen Species (ROS) generation. The data indicate that the biological properties of released quercetin are maintained in the presence of the host nanocarriers. Collectively, the findings suggest that the emerging hybrid nano-formulations can function as efficient nanocarriers of hydrophobic natural flavonoids in the development of multifunctional nanomaterials toward therapeutic applications.
Citation
Halevas, E., Mavroidi, B., Nday, C. M., Tang, J., Smith, G. C., Boukos, N., Litsardakis, G., Pelecanou, M., & Salifoglou, A. (2020). Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity. Journal of Inorganic Biochemistry, 213, 111271. https://doi.org/10.1016/j.jinorgbio.2020.111271
Publisher
Elsevier
Journal
Journal of Inorganic Biochemistry
Research Unit
DOI
10.1016/j.jinorgbio.2020.111271
PubMed ID
PubMed Central ID
Type
Article
Language
Description
Series/Report no.
ISSN
0162-0134