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Prenatal exposures and exposomics of asthma
Choi, Hyunok Mc Auley, Mark T. Lawrence, David A.
Choi, Hyunok
Mc Auley, Mark T.
Lawrence, David A.
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Publication Date
2015-02-19
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Abstract
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media
Citation
Choi, H., Mc Auley, M. T., & Lawrence, D. A. (2015). Prenatal exposures and exposomics of asthma. AIMS Environmental Science, 2(1), 87-109.
Publisher
AIMS Press
Journal
AIMS Environmental Science
Research Unit
DOI
10.3934/environsci.2015.1.87
PubMed ID
PubMed Central ID
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Article
Language
en_US