Mortality in type 2 diabetes mellitus: Magnitude of the evidence from a systematic review and meta-analysis
Nwaneri, Chukwuemeka Cooper, Helen Bowen-Jones, David
Nwaneri, Chukwuemeka
Cooper, Helen
Bowen-Jones, David
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Other Contributors
EPub Date
Publication Date
2013-07-15
Submitted Date
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Abstract
Type 2 diabetes is associated with an increase in age-related mortality. A systematic review and metaanalysis were performed to define the relative risks (RR) of all-cause or cause-specific mortality in type 2 diabetes and to determine gaps in current research. A comprehensive literature search was undertaken for studies (published 1990–2010) on mortality in type
2 diabetes. The study reports on the measure of mortality as defined by RR for all-cause and cause-specific mortality, heterogeneity, sensitivity analyses and biases. In total 35 studies (220,689 patients; mean follow-up of 10.7 years) were eligible for inclusion: 33 studies
reported increased mortality risks; 24 had full data on 95% confidence intervals (CIs), one study reported no excess mortality in men diagnosed after 65 years whereas three reported increased mortality in similar age groups in both
sexes. Meta-analysis showed RR = 1.85 (95% CI 1.79–1.92) for all-cause mortality [men RR=1.57 (95% CI 1.46–1.68); women RR=2.0 (95% CI 1.89–2.12)], RR=1.76 (95% CI 1.66–1.88) for cardiovascular mortality and RR=2.26 (95% CI:
1.7-3.02) for stroke. There was no statistically significant evidence of publication bias.
Conclusion: Type 2 diabetes increases mortality approximately two-fold increase and macrovascular disease is the principal cause of death.
Citation
British Journal of Diabetes & Vascular Disease, 2013, 13(4), pp.192-207
Publisher
SAGE Publications
Journal
British Journal of Diabetes & Vascular Disease
Research Unit
DOI
10.1177/1474651413495703
PubMed ID
PubMed Central ID
Type
Article
Language
en
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Series/Report no.
ISSN
1474-6514
EISSN
1753-4305