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Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
Reeve, Sarah Nickless, Alecia Sheaves, Bryony Stewart, Suzanne L. K. Gumley, Andrew I. Fowler, David Morrison, Anthony P. Freeman, David
Reeve, Sarah
Nickless, Alecia
Sheaves, Bryony
Stewart, Suzanne L. K.
Gumley, Andrew I.
Fowler, David
Morrison, Anthony P.
Freeman, David
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Other Contributors
EPub Date
Publication Date
2018-08-16
Submitted Date
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Abstract
Sleep disturbance is common among individuals at risk of psychosis, yet few studies have investigated the relationship between sleep disturbance and clinical trajectory. The Early Detection and Intervention Evaluation (EDIE-2) trial provides longitudinal data on sleep duration and individual psychotic experiences from a cohort of individuals at risk of psychosis, which this study utilises in an opportunistic secondary analysis. Shorter and more variable sleep was hypothesised to be associated with more severe psychotic experiences and lower psychological wellbeing. Mixed effect models were used to test sleep duration and range as predictors of individual psychotic experiences and psychological wellbeing over the 12-24 months (with assessments every 3 months) in 160 participants. Shorter sleep duration was associated with more severe delusional ideas and hallucinations cross-sectionally and longitudinally. The longitudinal relationships did not remain significant after conservative controls were added for the previous severity of psychotic experiences. No significant relationships were found between the sleep variables and other psychotic experiences (e.g. cognitive disorganisation), or psychological wellbeing. The results support a relationship between shorter sleep duration and delusional ideas and hallucinations. Future studies should focus on improving sleep disturbance measurement, and test whether treating sleep improves clinical trajectory in the at-risk group.
Citation
Reeve, S., Nickless, A., Sheaves, B., Stewart, S. L. K., Gumley, A., Fowler, D., Morrison, A., & Freeman, D. (2019). Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial. Schizophrenia Research, 204 (February 2019), 326-333. https://doi.org/10.1016/j.schres.2018.08.006
Publisher
Elsevier
Journal
Schizophrenia Research
Research Unit
DOI
10.1016/j.schres.2018.08.006
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
0920-9964
EISSN
1573-2509