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Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease

McCaddon, Andrew
; 
Bleenow, Kaj
; 
Hudson, Peter R.
; 
Hughes, Alan
; 
Barber, Joan
; 
Gray, Rob
; 
Davies, Gareth K.
; 
Williams, John H. H.
; 
Duguid, Jennifer
; 
Lloyd, Alwyn
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Affiliation
University of Wales College of Medicine; University of Goteborg; Wrexham Maelor Hospital; Royal Alexandra Hospital; Garnock Day Hospital/Ayrshire Central Hospital; University College Chester; University Hospital of Wales; Huddinge University Hospital
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2004-03-17
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Biological Sciences
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Abstract
Isoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.
Citation
McCaddon, A., Bleenow, K., Hudson, P. R., Hughes, A., Barber, J., Gray, R., Davies, G. K., Williams, J. H. H., Duguid, J., Lloyd, A., Tandy, S., Everall, M., Cattell, H., McCaddon, A., Ellis, D., Palmer, M., Bogdanovic, N., Gottfires, C-G., Zetterberg, H., ... Regland, B. (2004). Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 17(3), 215-221. https://doi.org/10.1159/000076359
Publisher
Karger Publishers
Journal
Dementia and Geriatric Cognitive Disorders
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URI
http://hdl.handle.net/10034/70457
DOI
10.1159/000076359
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Article
Language
en
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1420-8008
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This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
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http://www.karger.com