Thumbnail Image
Publication

Effect of lactational low-protein diet on skeletal muscle during adulthood and ageing in male and female mouse offspring

Alameddine, Moussira
; 
Altinpinar, Atilla Emre
; 
Ersoy, Ufuk
; 
Kanakis, Ioannis
; 
Myrtziou, Ioanna
; 
Ozanne, Susan E
; 
Goljanek-Whysall, Katarzyna
; 
Vasilaki, Aphrodite
Advisors
Editors
Other Contributors
Affiliation
University of Liverpool; University of Manchester; University of Chester; University of Cambridge; University of Galway
EPub Date
Publication Date
2024-09-01
Submitted Date
Collections
Chester Medical School
Show all metadata
Files
Thumbnail Image
Article - VoR
Adobe PDF, 3.43 MB
Other Titles
Abstract
Sarcopenia is characterised by the loss of skeletal muscle mass and function, which leads to a high risk of increased morbidity and mortality. Maternal malnutrition has been linked to impaired development of skeletal muscle of the offspring; however, there are limited studies that report the long-term effect of a maternal low-protein diet during lactation on the ageing of skeletal muscles. This study aimed to examine how a maternal low-protein diet (LPD) during lactation affects skeletal muscle ageing in the offspring. Pups born from control mothers were lactated by mothers fed with an LPD. Post-weaning, mice were either maintained on an LPD or switched to a control, normal-protein diet (NPD). In males, an LPD mainly affected the size of the myofibres without a major effect on fibre number and led to reduced grip strength in ageing mice (24 months). Female mice from mothers on an LPD had a lower body and muscle weight at weaning but caught up with control mice at 3 months. During ageing, the muscle weight, myofibre number and survival rate of female pups were significantly affected. These findings highlight the effect of an LPD during lactation on skeletal muscle ageing, the lifespan of offspring and the importance of sexual dimorphism in response to dietary challenges.
Citation
Alameddine, M., Altinpinar, A.E., Ersoy, U., Kanakis, I., Myrtziou, I., Ozanne, S.E., Goljanek-Whysall, K. and Vasilaki, A. (2024). Effect of Lactational Low-Protein Diet on Skeletal Muscle during Adulthood and Ageing in Male and Female Mouse Offspring. Nutrients, 16(17), 2926. https://doi.org/10.3390/nu16172926
Publisher
MDPI
Journal
Nutrients
Research Unit
URI
http://hdl.handle.net/10034/628989
DOI
10.3390/nu16172926
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
2072-6643
ISBN
ISMN
Gov't Doc
Test Link
Sponsors
Biotechnology and Biological Sciences Research Council and the Institute of Life Course and Medical Sciences, University of Liverpool
Additional Links
http://dx.doi.org/10.3390/nu16172926