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Antibacterial, Remineralizing Zinc Oxide-Doped Phosphate-Based Glasses
Rajadorai, Sindhuja Harris, Genevieve Robinson, Alistair Miles, Emma J. Roberts, Jonathan Cooper, Lee Abou Neel, Ensanya A. Higham, Susan M. Flannigan, Norah L Valappil, Sabeel P.
Rajadorai, Sindhuja
Harris, Genevieve
Robinson, Alistair
Miles, Emma J.
Roberts, Jonathan
Cooper, Lee
Abou Neel, Ensanya A.
Higham, Susan M.
Flannigan, Norah L
Valappil, Sabeel P.
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EPub Date
Publication Date
2021-09-11
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Abstract
This study reports a novel melt quenched zinc oxide-doped phosphate-based glasses (Zn-PBGs) of varying CaO mol% designated as C11, C12, C13. The glass degradation rate, ions release, antibacterial activity against S. mutans and remineralization potential were investigated. Zn-PBGs showed one order of magnitude higher degradation rate than Zn-free PBG. The highest rate was observed for C11; Na+, Ca2+, Zn2+ and P5+ release followed the same trend. The higher the Zn2+ release, the greater the S. mutans growth inhibition. C11 showed significantly lower mineral loss from enamel than positive and negative controls. Zn-PBGs could be used to reverse enamel demineralization.
Citation
Rajadorai, S., Harris, G., Robinson, A., Miles, E. J., Roberts, J. M., Cooper, L., Abou Neel, E.A., Higham, SM., Flannigan N.L., & Valappil, S. P. (2022). Antibacterial, remineralising zinc oxide-doped phosphate-based glasses. Materials Letters. 306, 130813. https://doi.org/10.1016/j.matlet.2021.130813
Publisher
Elsevier
Journal
Materials Letters
Research Unit
DOI
10.1016/j.matlet.2021.130813
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PubMed Central ID
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Article
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Series/Report no.
ISSN
0167-577X