Thumbnail Image
Publication

Maternal obesity and metabolic (dysfunction) associated fatty liver disease in pregnancy: a comprehensive narrative review

Leca, Bianca M.
; 
Lagojda, Lukasz
; 
Kite, Chris
; 
Karteris, Emmanouil
; 
Kassi, Eva
; 
Randeva, Harpal S.
; 
Kyrou, Ioannis
Advisors
Editors
Other Contributors
Affiliation
University Hospitals Coventry and Warwickshire NHS Trust; University of Warwick; University of Wolverhampton; Coventry University; University of Chester; Brunel University London; National and Kapodistrian University of Athens; Aston University; University of Derby; Agricultural University of Athens
EPub Date
Publication Date
2024-06-11
Submitted Date
Collections
Chester Medical School
Show all metadata
Files
Thumbnail Image
Article - VoR
Adobe PDF, 2.9 MB
Other Titles
Abstract
Introduction: Obesity and metabolic-associated fatty liver disease (MAFLD) during pregnancy constitute significant problems for routine antenatal care, with increasing prevalence globally. Similar to obesity, MAFLD is associated with a higher risk for maternal complications (e.g. pre-eclampsia and gestational diabetes) and long-term adverse health outcomes for the offspring. However, MAFLD during pregnancy is often under-recognized, with limited management/treatment options. Areas covered: PubMed/MEDLINE, EMBASE, and Scopus were searched based on a search strategy for obesity and/or MAFLD in pregnancy to identify relevant papers up to 2024. This review summarizes the pertinent evidence on the relationship between maternal obesity and MAFLD during pregnancy. Key mechanisms implicated in the underlying pathophysiology linking obesity and MAFLD during pregnancy (e.g. insulin resistance and dysregulated adipokine secretion) are highlighted. Moreover, a diagnostic approach for MAFLD diagnosis during pregnancy and its complications are presented. Finally, promising relevant areas for future research are covered. Expert opinion: Research progress regarding maternal obesity, MAFLD, and their impact on maternal and fetal/offspring health is expected to improve the relevant diagnostic methods and lead to novel treatments. Thus, routine practice could apply more personalized management strategies, incorporating individualized algorithms with genetic and/or multi-biomarker profiling to guide prevention, early diagnosis, and treatment.
Citation
Leca, B. M., Lagojda, L., Kite, C., Karteris, E., Kassi, E., Randeva, H. S., & Kyrou, I. (2024). Maternal obesity and metabolic (dysfunction) associated fatty liver disease in pregnancy: a comprehensive narrative review. Expert Review of Endocrinology & Metabolism, 19(4), 335-348. https://doi.org/10.1080/17446651.2024.2365791
Publisher
Taylor & Francis
Journal
Expert Review of Endocrinology & Metabolism
Research Unit
URI
http://hdl.handle.net/10034/629180
DOI
10.1080/17446651.2024.2365791
PubMed ID
PubMed Central ID
Type
Article
Language
Description
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Series/Report no.
ISSN
1744-6651
EISSN
1744-8417
ISBN
ISMN
Gov't Doc
Test Link
Sponsors
Unfunded
Additional Links
https://www.tandfonline.com/doi/full/10.1080/17446651.2024.2365791