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Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy
Nye, Gareth Sakellariou, Giorgos Pearson, Timothy Lightfoot, Adam Wells, Nicola Giakoumaki, Ifigeneia Vasilaki, Aphrodite Griffiths, Richard Jackson, Malcolm McArdle, Anne
Nye, Gareth
Sakellariou, Giorgos
Pearson, Timothy
Lightfoot, Adam
Wells, Nicola
Giakoumaki, Ifigeneia
Vasilaki, Aphrodite
Griffiths, Richard
Jackson, Malcolm
McArdle, Anne
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Publication Date
2016-09-29
Submitted Date
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srep33944.pdf
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Abstract
Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role of age-dependent mitochondrial dysfunction and cumulative oxidative stress as the underlying cause of muscle aging remains a controversial topic. Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice. However, this treatment failed to rescue the age-related muscle fiber atrophy associated with muscle atrophy and weakness. Collectively, these data imply that the muscle mitochondrial redox environment is not a key regulator of muscle fiber atrophy during sarcopenia but may play a key role in the decline of mitochondrial organelle integrity that occurs with muscle aging.
Citation
Sakellariou, G., Pearson, T., Lightfoot, A., Nye, G., Wells, N., Giakoumaki, I., . . . McArdle, A. (2016). Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy. Scientific Reports, 6(1), 33944
Publisher
Nature Research
Journal
Scientific Reports
Research Unit
DOI
10.1038/srep33944
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
2045-2322