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Mechanisms of skeletal muscle ageing: avenues for therapeutic intervention
Nye, Gareth McCormick, Rachel Lightfoot, Adam McArdle, Anne
Nye, Gareth
McCormick, Rachel
Lightfoot, Adam
McArdle, Anne
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Publication Date
2014-05-28
Submitted Date
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Other Titles
Abstract
Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of life of older people. The mechanisms underlying sarcopenia are unclear and the development of optimal therapeutic interventions remains elusive. Impaired regenerative capacity, attenuated ability to respond to stress, elevated reactive oxygen species production and low-grade systemic inflammation are all key contributors to sarcopenia. Pharmacological intervention using compounds such as 17AAG, SS-31 and Bimagrumab or naturally occurring polyphenols to target specific pathways show potential benefit to combat sarcopenia although further research is required, particularly to identify the mechanisms by which muscle fibres are completely lost with increasing age.
Citation
Lightfoot, A. P., McCormick, R., Nye, G. A., & McArdle, A. (2014). Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention. Current Opinion in Pharmacology, 16, 116-121.
Publisher
Elsevier
Journal
Current Opinion in Pharmacology
Research Unit
DOI
10.1016/j.coph.2014.05.005
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
1471-4892
EISSN
1471-4973