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Size at birth and cognitive ability in late life: A systematic review
Krishna, Murali Jones, Steven Maden, Michelle Du, Bharath Mc, Ramya Kumaran, Kalyanaraman Karat, Samuel C. Fall, Caroline H. D.
Krishna, Murali
Jones, Steven
Maden, Michelle
Du, Bharath
Mc, Ramya
Kumaran, Kalyanaraman
Karat, Samuel C.
Fall, Caroline H. D.
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Editors
Other Contributors
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EPub Date
Publication Date
2019-05-06
Submitted Date
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Abstract
Introduction: Recent evidence suggests that growth restriction in utero and programming of metabolism may lead to neurocognitive disorders in late life.
Methods: Systematic review of literature investigating the relationship between size
at birth and cognitive abilities in late life according to PRISMA guideline. The search,
data extraction and rating for the quality of reporting were conducted independently
by two researchers.
Results; Eight of the eleven eligible studies, from higher income settings, showed a
direct association of size at birth with cognitive abilities in late life. Socioeconomic
position at birth and education are important determinants of late life cognition is insufficient evidence from this review to support the DOHaD cognitive reserve or cardiometabolic pathways of cognitive ageing.
Discussion: Education may supersede and may even compensate for vulnerabilities
in early life to late life cognitive impairment. Similarly, interventions aimed to improve
growth and development in early life and childhood may also enhance the brain
reserve and lead to higher cognitive abilities in late life.
Citation
Krishna, M., Jones, S., Maden, M., Du, B., Mc, R., Kumaran, K., . . . Fall, C. H. D. (2019). Size at birth and cognitive ability in late life: A systematic review. International Journal of Geriatric Psychiatry, 34(8), 1139-1169.
Publisher
Wiley
Journal
International Journal of Geriatric Psychiatry
Research Unit
DOI
10.1002/gps.5138
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
0885-6230
EISSN
1099-1166