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Obesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Aging

Morgan, Amy
; 
Mooney, Kathleen M.
; 
Mc Auley, Mark T.
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Affiliation
University of Chester; Edge Hill University
EPub Date
Publication Date
2016-10-17
Submitted Date
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Chemical Engineering
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Abstract
The population of the world is aging. In 2010, an estimated 524 million people were aged 65 years or older presenting eight percent of the global population. By 2050, this number is expected to nearly triple to approximately 1.5 billion, 16 percent of the world’s population. Although people are living longer, the quality of their lives are often compromised due to ill-health. Areas covered. Of the conditions which compromise health as we age, obesity is at the forefront. Over half of the global older population were overweight or obese in 2010, significantly increasing the risk of a range of metabolic diseases. Although, it is well recognised excessive calorie intake is a fundamental driver of adipose tissue dysfunction, the relationship between obesity; intrinsic aging; and fat metabolism is less understood. In this review we discuss the intersection between obesity, aging and the factors which contribute to the dysregulation of whole-body fat metabolism. Expert Commentary. Being obese disrupts an array of physiological systems and there is significant crosstalk among these. Moreover it is imperative to acknowledge the contribution intrinsic aging makes to the dysregulation of these systems and the onset of disease.
Citation
Morgan, A., Mooney, K., Mc Auley, M. T. (2016). Obesity and the Dysregulation of Fatty Acid Metabolism: Implications for Healthy Aging. Expert Review of Endocrinology & Metabolism, 11(6), 501-510. DOI: 10.1080/17446651.2016.1245141
Publisher
Taylor & Francis
Journal
Expert Review of Endocrinology & Metabolism
Research Unit
URI
http://hdl.handle.net/10034/620190
DOI
10.1080/17446651.2016.1245141
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Endocrinology & Metabolism on 17/10/2016, available online: http://dx.doi.org/10.1080/17446651.2016.1245141
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EISSN
1744-8417
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http://www.tandfonline.com/toc/iere20/current