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Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

Movahedpour, Ahmad
; 
Taghvaeefar, Rasul
; 
Asadi‐Pooya, Ali‐Akbar
; 
Karami, Yousof
; 
Tavasolian, Ronia
; 
Khatami, Seyyed H.
; 
Soltani Fard, Elahe
; 
Taghvimi, Sina
; 
Karami, Neda
; 
Rahimi Jaberi, Khojaste
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Affiliation
Behbahan Faculty of Medical Sciences; Shiraz University of Medical Sciences; Thomas Jefferson University; Shahid Bahonar University of Kerman; University of Chester; Shahid Beheshti University of Medical Sciences; Shahrekord University of Medical Sciences; Shahid Chamran University of Ahvaz; Institute of Solid State Electronics, Vienna; Urmia University of Medical Sciences
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2023-07-14
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Clinical Sciences and Nutrition
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Abstract
Epilepsy is a common chronic neurological disorder caused by aberrant neuronal electrical activity. Antiseizure medications (ASMs) are the first line of treatment for people with epilepsy (PWE). However, their effectiveness may be limited by their inability to cross the blood–brain barrier (BBB), among many other potential underpinnings for drug resistance in epilepsy. Therefore, there is a need to overcome this issue and, hopefully, improve the effectiveness of ASMs. Recently, synthetic nanoparticle‐based drug delivery systems have received attention for improving the effectiveness of ASMs due to their ability to cross the BBB. Furthermore, exosomes have emerged as a promising generation of drug delivery systems because of their potential benefits over synthetic nanoparticles. In this narrative review, we focus on various synthetic nanoparticles that have been studied to deliver ASMs. Furthermore, the benefits and limitations of each nano‐delivery system have been discussed. Finally, we discuss exosomes as potentially promising delivery tools for treating epilepsy.
Citation
Movahedpour, A., Taghvaeefar, R., Asadi‐Pooya, A‐A., Karami, Y., Tavasolian, R., Khatami, S. H., Soltani Fard, E., Taghvimi, S., Karami, N., Rahimi Jaberi, K., Taheri‐Anganeh, M., & Ghasemi, H. (2023). Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives. CNS Neuroscience & Therapeutics, 29(11), 3150-3159. https://doi.org/10.1111/cns.14355
Publisher
Wiley Open Access
Journal
CNS Neuroscience & Therapeutics
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http://hdl.handle.net/10034/627920
DOI
10.1111/cns.14355
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article
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ISSN
1755-5930
EISSN
1755-5949
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https://onlinelibrary.wiley.com/doi/full/10.1111/cns.14355