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Sonic hedgehog specifies flight feather positional information in avian wings
Busby, Lara Aceituno, Cristina McQueen, Caitlin Rich, Constance Ros, Maria Towers, Matthew
Busby, Lara
Aceituno, Cristina
McQueen, Caitlin
Rich, Constance
Ros, Maria
Towers, Matthew
Advisors
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Other Contributors
EPub Date
Publication Date
2020-05-06
Submitted Date
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Article - VoR
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Abstract
Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional information required for the formation of adult flight feathers in a defined spatial and temporal sequence that reflects their different identities. We also reveal that Shh signalling is interpreted into specific patterns of Sim1 and Zic transcription factor expression, providing evidence of a putative gene regulatory network operating in flight feather patterning. Our data suggest that flight feather specification involved the co-option of the pre-existing digit patterning mechanism and therefore uncovers an embryonic process that played a fundamental step in the evolution of avian flight.
Citation
Busby, L., Aceituno, C., McQueen, C., Rich, C. A., Ros, M. A., & Towers, M. (2020). Sonic hedgehog specifies flight feather positional information in avian wings. Development, 147(9), dev188821. https://doi.org/10.1242/dev.188821
Publisher
The Company of Biologists
Journal
Development
Research Unit
DOI
10.1242/dev.188821
PubMed ID
PubMed Central ID
Type
Article
Language
Description
Series/Report no.
ISSN
0950-1991
EISSN
1477-9129