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Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression
Dallaway, Alexander Kite, Chris Griffin, Corbyn Duncan, Michael Tallis, Jason Renshaw, Derek Hattersley, John
Dallaway, Alexander
Kite, Chris
Griffin, Corbyn
Duncan, Michael
Tallis, Jason
Renshaw, Derek
Hattersley, John
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Other Contributors
EPub Date
Publication Date
2020-01-30
Submitted Date
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Abstract
Morphological changes of the lumbar spine muscles are not well characterised with ageing. To further the understanding of age-related degeneration of the lumbar spine musculature, normative morphological changes that occur within the paravertebral muscles must first be established.
Methods
A systematic review and meta-regressions were conducted adhering to PRISMA guidelines. Searches for published and unpublished data were completed in June 2019.
Results
Searches returned 4781 articles. 34 articles were included in the quantitative analysis. Three-level meta-analyses showed age-related atrophy (r = −0.26; 95% CI: −0.33, −0.17) and fat infiltration (r = 0.39; 95% CI: 0.28, 0.50) in the lumbar paravertebral muscles. Degenerative changes were muscle-specific and men (r = −0.32; 95% CI: −0.61, 0.01) exhibited significantly greater muscle atrophy than women (r = −0.24; 95% CI: −0.47, 0.03). Imaging modality, specifically ultrasound, also influenced age-related muscle atrophy. Measurements taken across all lumbar levels revealed the greatest fat infiltration with ageing (r = 0.58, 95% CI: 0.35, 0.74). Moderators explained a large proportion of between-study variance in true effects for muscle atrophy (72.6%) and fat infiltration (79.8%) models.
Conclusions
Lumbar paravertebral muscles undergo age-related degeneration in healthy adults with muscle, lumbar level and sex-specific responses. Future studies should use high-resolution imaging modalities to quantify muscle atrophy and fat infiltration.
Citation
Dallaway, A., Kite, C., Griffen, C., Duncan, M., Tallis, J., Renshaw, D., & Hattersley, J. (2020). Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression. Experimental Gerontology, 133, 110856. https://doi.org/10.1016/j.exger.2020.110856
Publisher
Elsevier
Journal
Experimental Gerontology
Research Unit
DOI
10.1016/j.exger.2020.110856
PubMed ID
PubMed Central ID
Type
Article
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Description
Series/Report no.
ISSN
EISSN
1873-6815