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Event-related and readiness potentials when preparing to approach and avoid alcohol cues following cue avoidance training in heavy drinkers.
Stancak, Andrej Soto, Vicente Fallon, Nick Di Lemma, Lisa
Stancak, Andrej
Soto, Vicente
Fallon, Nick
Di Lemma, Lisa
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Abstract
Rationale Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that
underlie the effects of this intervention are poorly understood.
Objectives The present study investigated the effects of a single session of CAT on event-related and readiness potentials during
preparation of approach and avoidance movements to alcohol cues.
Methods Heavy drinking young adults (N = 60) were randomly assigned to complete either CAT or control training. After
training, we recorded participants’ event-related and motor readiness potentials as they were preparing to respond.
Results In the CAT group, N200 amplitude was higher when preparing to approach rather than avoid alcohol pictures. In the
control group, N200 amplitudes did not differ for approach and avoidance to alcohol pictures. Regarding the late positive
potential (LPP), in the CAT group, the negativity of this was blunted when preparing to avoid alcohol pictures relative to when
preparing to avoid control pictures. In the control group, the negativity of the LPP was blunted when preparing to approach
alcohol pictures relative to when preparing to approach control pictures. There were no effects on motor readiness potentials.
Behavioural effects indicated short-lived effects of training on reaction times during the training block that did not persist when
participants were given time to prepare their motor response before executing it during the EEG testing block.
Conclusions After a single session of CAT, the enhanced N200 when approaching alcohol cues may indicate the engagement of
executive control to overcome the associations learned during training. These findings clarify the neural mechanisms that may
underlie the effects of CAT on drinking behaviour.
Citation
Di Lemma, L. C., Stancak, A., Soto, V., Fallon, N., & Field, M. (2020). Event-related and readiness potentials when preparing to approach and avoid alcohol cues following cue avoidance training in heavy drinkers. Psychopharmacology, 237, 1343–1358. https://doi.org/10.1007/s00213-020-05462-7
Publisher
Springer
Journal
Psychopharmacology
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DOI
10.1007/s00213-020-05462-7
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Article
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Description
This is a post-peer-review, pre-copyedit version of an article published in Psychopharmacology. The final authenticated version is available online at: https://doi.org/10.1007/s00213-020-05462-7
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1432-2072