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Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner
Pugh, Jamie Sage, Stephen Hutson, Mark Doran, Dominic Fleming, Simon Highton, Jamie Morton, James P. Close, Graeme L.
Pugh, Jamie
Sage, Stephen
Hutson, Mark
Doran, Dominic
Fleming, Simon
Highton, Jamie
Morton, James P.
Close, Graeme L.
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EPub Date
Publication Date
2017-10-20
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Abstract
Purpose To examine the dose–response effects of acute glutamine supplementation on markers of gastrointestinal
(GI) permeability, damage and, secondary, subjective symptoms of GI discomfort in response to running in the heat.
Methods Ten recreationally active males completed a total of four exercise trials; a placebo trial and three glutamine
trials at 0.25, 0.5 and 0.9 g kg−1 of fat-free mass (FFM) consumed 2 h before exercise. Each exercise trial consisted
of a 60-min treadmill run at 70% of ̇VO2max in an environmental chamber set at 30 °C. GI permeability was measured
using ratio of lactulose to rhamnose (L:R) in serum. Plasma glutamine and intestinal fatty acid binding protein
(I-FABP) concentrations were determined pre and post exercise. Subjective GI symptoms were assessed 45 min and 24 h
post-exercise. Results Relative to placebo, L:R was likely lower following 0.25 g kg−1 (mean difference: − 0.023; ± 0.021) and
0.5 g kg−1 (− 0.019; ± 0.019) and very likely following 0.9 g kg− 1 (− 0.034; ± 0.024). GI symptoms were typically low
and there was no effect of supplementation. Discussion Acute oral glutamine consumption attenuates
GI permeability relative to placebo even at lower doses of 0.25 g kg−1, although larger doses may be more effective. It remains unclear if this will lead to reductions in GI symptoms. Athletes competing in the heat may, therefore, benefit
from acute glutamine supplementation prior to exercise in order to maintain gastrointestinal integrity.
Citation
Pugh, J. N., Sage, S., Hutson, M., Doran, D. A., Fleming, S. C., Highton, J., . . . Close, G. L. (2017). Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner. European Journal of Applied Physiology, 117(12), 2569-2577. doi:10.1007/s00421-017-3744-4
Publisher
Springer
Journal
European Journal of Applied Physiology
Research Unit
DOI
10.1007/s00421-017-3744-4
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PubMed Central ID
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Article
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ISSN
EISSN
1439-6327