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In vitro erythropoiesis: The emerging potential of induced pluripotent stem cells (iPSCs)
Chukwuemeka, Chidera G. Ndubueze, Chizaram W. Kolawole, Adeola V. Joseph, Joshua N. Oladipo, Ifeoluwa H. Ofoezie, Ezichi F. Annor-Yeboah, Samuel A. Bello, Abdur-Rahman Eneye Ganiyu, Sodiq O.
Chukwuemeka, Chidera G.
Ndubueze, Chizaram W.
Kolawole, Adeola V.
Joseph, Joshua N.
Oladipo, Ifeoluwa H.
Ofoezie, Ezichi F.
Annor-Yeboah, Samuel A.
Bello, Abdur-Rahman Eneye
Ganiyu, Sodiq O.
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2024-12-26
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Abstract
Due to global blood shortages and restricted donor blood storage, the focus has switched to the in vitro synthesis of red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) as a potential solution. Many processes are required to synthesize RBCs from iPSCs, including the production of iPSCs from human or animal cells, differentiation of iPSCs into hematopoietic stem cells, culturing, and maturation of the hematopoietic stem cells (HSC) to make functional erythrocytes. Previous investigations on the in vitro production of erythrocytes have shown conflicting results. Some studies have demonstrated substantial yields of functional erythrocytes, whereas others have observed low yields of enucleated cells. Before large-scale in vitro RBC production can be achieved, several challenges which have limited its application in the clinic must be overcome. These issues include optimizing differentiation techniques to manufacture vast amounts of functional RBCs, upscaling the manufacturing process, cost-effectiveness, and assuring the production of RBCs with good manufacturing practices (GMP) before they can be used for therapeutic purposes.
Citation
Chukwuemeka, C. G., Ndubueze, C. W., Kolawole, A. V., Joseph, J. N., Oladipo, I. H., Ofoezie, E. F., Annor-Yeboah, S. A., Bello, A.-R. E., & Ganiyu, S. O. (2025). In vitro erythropoiesis: The emerging potential of induced pluripotent stem cells (iPSCs). Blood Science, 7(1), e00215. https://doi.org/10.1097/BS9.0000000000000215
Publisher
Wolters Kluwer Health
Journal
Blood Science
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DOI
10.1097/BS9.0000000000000215
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Article
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Copyright © 2024 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences
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2543-6368
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