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Proteomic analysis and effects on osteogenic differentiation of exosomes from patients with ossification of the spinal ligament

Nakajima, Hideaki
; 
Johnson, William E. B.
; 
Kamitani, Mikiko
; 
Watanabe, Shuji
; 
Honjoh, Kazuya
; 
Kubota, Arisa
; 
Matsumine, Akihiko
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Affiliation
Sciences, University of Fukui; University of Chester
EPub Date
Publication Date
2025-02-02
Submitted Date
Collections
Chester Medical School
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Abstract
Lay Summary: Ossification of ligamentum flavum (OLF) is a hyperostotic spinal condition that compresses the spinal cord, leading to progressive motor and sensory dysfunction. Progression of ossification varies widely among individuals, making it important to identify factors that regulate disease activity. The study focused on exosomes, crucial for intercellular communication during disease development and progression. By comparing exosomes from patients with and without OLF, the study identified specific proteins that may play a role in spinal ligament ossification. These findings could help identify new markers to track disease progression and potential targets for treatment.
Citation
Nakajima, H., Johnson, W. E. B., Kamitani, M., Watanabe, S., Honjoh, K., Kubota, A., & Matsumine, A. (2025). Proteomic analysis and effects on osteogenic differentiation of exosomes from patients with ossification of the spinal ligament. JBMR Plus, 9(4), article-number ziaf021. https://doi.org/10.1093/jbmrpl/ziaf021
Publisher
Oxford University Press
Journal
JBMR Plus
Research Unit
URI
http://hdl.handle.net/10034/629300
DOI
10.1093/jbmrpl/ziaf021
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PubMed Central ID
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Article
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Description
© The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.
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ISSN
EISSN
2473-4039
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Sponsors
This study was supported by Uehara Memorial Foundation Research grants (Grant Number 202220132), grants-in-aid for Scientific Research (Grant Number JP22K09327), Grant of Japan Orthopaedics and Traumatology Research Foundation No. 494, and the Investigation Committee on Ossification of Spinal Ligaments, Public Health Bureau of the Japanese Ministry of Labor, Health, and Welfare.
Additional Links
https://academic.oup.com/jbmrplus/article/9/4/ziaf021/7996448