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3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities

Aldhaher, Abdullah
; 
Shahabipour, Fahimeh
; 
Shaito, Abdullah
; 
Al-Assaf, Saphwan
; 
Elnour, Ahmed
; 
Sallam, El Bashier
; 
Teimourtash, Shahin
; 
Elfadil, Abdelgadir A.
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Affiliation
Sharif University of Technology; Mashhad University of Medical Science; Shahid Beheshti University of Medical Sciences; Qatar University; University of Chester; University of Malaysia Pahang-UMP; Freelance Global and Public Health Expert (FGPHE), Sudan; McMaster University; Al-Neelain University
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2023-07-05
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Clinical Sciences and Nutrition
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Abstract
Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporates bioactive glass to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offers regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the future challenges of manufacturing such biomaterials.
Citation
Aldhaher, A., Shahabipour, F., Shaito, A., Al-Assaf, S., Elnour, A., Sallam, E. B., Teimourtash, S., & Elfadil, A. A. (2023). 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities. Heliyon, 9(7), article-number e17050. https://doi.org/10.1016/j.heliyon.2023.e17050
Publisher
Elsevier
Journal
Heliyon
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http://hdl.handle.net/10034/627905
DOI
10.1016/j.heliyon.2023.e17050
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Article
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2405-8440
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https://www.sciencedirect.com/science/article/pii/S2405844023042585