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A single dose of ChAdOx1 Chik vaccine induces neutralising antibodies against four chikungunya virus lineages in a phase 1 clinical trial
Folegatti, Pedro M. Harrison, Kate Preciado-Llanes, Lorena Ramos Lopez, Fernando Bittaye, Mustapha Kim, Young Chan Flaxman, Amy Bellamy, Duncan Makinson, Rebecca Sheridan, Jonathan
Folegatti, Pedro M.
Harrison, Kate
Preciado-Llanes, Lorena
Ramos Lopez, Fernando
Bittaye, Mustapha
Kim, Young Chan
Flaxman, Amy
Bellamy, Duncan
Makinson, Rebecca
Sheridan, Jonathan
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Publication Date
2021-07-30
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Abstract
Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that causes swift outbreaks. Major concerns are the persistent and disabling polyarthralgia in infected individuals. Here we present the results from a first-in-human trial of the candidate simian adenovirus vectored vaccine ChAdOx1 Chik, expressing the CHIKV full-length structural polyprotein (Capsid, E3, E2, 6k and E1). 24 adult healthy volunteers aged 18–50 years, were recruited in a dose escalation, open-label, nonrandomized and uncontrolled phase 1 trial (registry NCT03590392). Participants received a single intramuscular injection of ChAdOx1 Chik at one of the three preestablished dosages and were followed-up for 6 months. The primary objective was to assess safety and tolerability of ChAdOx1 Chik. The secondary objective was to assess the humoral and cellular immunogenicity. ChAdOx1 Chik was safe at all doses tested with no serious adverse reactions reported. The vast majority of solicited adverse events were mild or moderate, and self-limiting in nature. A single dose induced IgG and Tcell responses against the CHIKV structural antigens. Broadly neutralizing antibodies against the four CHIKV lineages were found in all participants and as early as 2 weeks after vaccination. In summary, ChAdOx1 Chik showed excellent safety, tolerability and 100% PRNT50 seroconversion after a single dose.
Citation
Folegatti, P. M., Harrison, K., Preciado-Llanes, L., Lopez, F. R., Bittaye, M., Kim, Y. C., Flaxman, A., Bellamy, D., Makinson, R., Sheridan, J., Azar, S. R., Campos, R. K., Tilley, M., Tran, N., Jenkin, D., Poulton, I., Lawrie, A., Roberts, R., Berrie, E., . . . Reyes-Sandoval, A. (2021). A single dose of ChAdOx1 chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial. Nature Communications, 12(1), 4636. https://doi.org/10.1038/s41467-021-24906-y
Publisher
Nature Research
Journal
Nature Communications
Research Unit
DOI
10.1038/s41467-021-24906-y
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PubMed Central ID
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Article
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EISSN
2041-1723