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Folate supplementation reduces serum Hsp70 levels in patients with type 2 diabetes

Hunter-Lavin, Claire
; 
Hudson, Peter R.
; 
Mukhergee, Sagarika
; 
Davies, Gareth K.
; 
Williams, Clive P.
; 
Harvey, John N.
; 
Child, David F.
; 
Williams, John H. H.
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Affiliation
University College Chester ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; Wrexham Maelor Hospital, North East Wales NHS Trust ; University College Chester
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Publication Date
2004-10
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Biological Sciences
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Abstract
Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 μM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non–insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease.
Citation
Cell Stress and Chaperones, 9(4), 2004, pp. 344–349
Publisher
Cell Stress Society International
Journal
Cell Stress and Chaperones
Research Unit
URI
http://hdl.handle.net/10034/69797
DOI
10.1379/CSC-28R.1.
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PubMed Central ID
Type
Article
Language
en
Description
This article is not available through ChesterRep. It is available through PubMed Central http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1065273
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1355-8145
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http://www.springer.com/biomed/journal/12192