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Mathematical modelling of metabolic regulation in aging
Mc Auley, Mark T. Mooney, Kathleen M. Angell, Peter J. Wilkinson, Stephen J.
Mc Auley, Mark T.
Mooney, Kathleen M.
Angell, Peter J.
Wilkinson, Stephen J.
Advisors
Editors
Other Contributors
Affiliation
University of Chester ; Liverpool Hope University ; Edge Hill University ; University of Chester
EPub Date
Publication Date
2015-04-27
Submitted Date
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Abstract
The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area.
Citation
Mc Auley, M. T., Mooney, K. M., Angell, P. J., & Wilkinson, S. J. (2015). Mathematical modelling of metabolic regulation in aging. Metabolites, 5(2), 232-251.
Publisher
MDPI
Journal
Metabolites
Research Unit
DOI
10.3390/metabo5020232
PubMed ID
PubMed Central ID
Type
Article
Language
en
Description
Series/Report no.
ISSN
2218-1989