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Regulation and roles of Ca2+ stores in human sperm.
Correia, Joao Michelangeli, Francesco Publicover, Stephen
Correia, Joao
Michelangeli, Francesco
Publicover, Stephen
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2015-05-11
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Abstract
[Ca(2)(+)]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2)(+)-permeable plasma membrane ion channel CatSper is central to [Ca(2)(+)]i signalling, but there is good evidence that Ca(2)(+) stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca(2)(+) stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca(2)(+)]i signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca(2)(+) channels and stored Ca(2)(+) may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca(2)(+)-signalling apparatus may interact to generate complex and spatially diverse [Ca(2)(+)]i signals.
Citation
Correia, J., Michelangeli, F., & Publicover, S. (2015). Regulation and roles of Ca2+ stores in human sperm. Reproduction, 150(2), R65-R76. doi:10.1530/rep-15-0102
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Bioscientifica
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Reproduction
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doi: 10.1530/REP-15-0102
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Article
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en
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1470-1626
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Wellcome Trust