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The efficacy and safety of ketamine for depression in patients with cancer: A systematic review
Azari, Leila Hemati, Homa Tavasolian, Ronia Shahdab, Sareh Tomlinson, Stephanie M. Bobonis Babilonia, Margarita Huang, Jeffrey Tometich, Danielle B. Turner, Kea Jim, Heather S. L.
Azari, Leila
Hemati, Homa
Tavasolian, Ronia
Shahdab, Sareh
Tomlinson, Stephanie M.
Bobonis Babilonia, Margarita
Huang, Jeffrey
Tometich, Danielle B.
Turner, Kea
Jim, Heather S. L.
Advisors
Editors
Other Contributors
EPub Date
Publication Date
2023-12-15
Submitted Date
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Abstract
Management of depression in the oncology population includes supportive psychotherapeutic interventions with or without psychotropic medication, which take time to demonstrate effectiveness. Fast-acting interventions, like ketamine, can provide a rapid antidepressant effect; however, there has been limited research on effects of ketamine among cancer patients. The objective of this review is to provide an overview of research on the efficacy and safety of ketamine on depression in patients with cancer. We reviewed the published literature in MEDLINE® (via PubMed®), EMBASE, and Scopus from 1 January 1982 to 20 October 2022. We screened the retrieved abstracts against inclusion criteria and conducted a full-text review of eligible studies. Following extraction of data from included studies, we used a framework analysis approach to summarize the evidence on using ketamine in patients with cancer. All 5 included studies were randomized clinical trials conducted in inpatient settings in China. In all included studies ketamine was administered intravenously. Three studies used only racemic ketamine, and two studies used both S-ketamine and racemic ketamine. All included studies reported ketamine a tolerable and effective drug to control depression symptoms. Included studies showed administration of sub-anesthesia ketamine significantly improves postoperative depression among patients with cancer. [Abstract copyright: © 2023 The Author(s).]
Citation
Azari, L., Hemati, H., Tavasolian, R., Shahdab, S.,
Tomlinson, S. M., Bobonis Babilonia, M., Huang, J.,
Tometich, D. B., Turner, K., Jim, H. S. L., & Tabriz, A. A. (2024). The efficacy and safety of ketamine for depression in patients with cancer: A systematic review. International Journal of Clinical and Health Psychology, 24(1), article-number 100428. https://doi.org/10.1016/j.ijchp.2023.100428
Publisher
Elsevier
Asociación Española de Psicología Conductual
Asociación Española de Psicología Conductual
Journal
International Journal of Clinical and Health Psychology
Research Unit
DOI
10.1016/j.ijchp.2023.100428
PubMed ID
PubMed Central ID
Type
Article
Language
Description
Series/Report no.
ISSN
2174-0852
EISSN
1697-2600