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Systems biology and synthetic biology: A new epoch for toxicology research
Mc Auley, Mark T. Choi, Hyunok Mooney, Kathleen M. Paul, Emily Miller, Veronica M.
Mc Auley, Mark T.
Choi, Hyunok
Mooney, Kathleen M.
Paul, Emily
Miller, Veronica M.
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Publication Date
2015-01-26
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Abstract
Systems biology and synthetic biology are emerging disciplines which are becoming increasingly utilised in several areas of bioscience. Toxicology is beginning to benefit from systems biology and we suggest in the future that is will also benefit from synthetic biology. Thus, a new era is on the horizon. This review illustrates how a suite of innovative techniques and tools can be applied to understanding complex health and toxicology issues. We review limitations confronted by the traditional computational approaches to toxicology and epidemiology research, using polycyclic aromatic hydrocarbons (PAHs) and their effects on adverse birth outcomes as an illustrative example. We introduce how systems toxicology (and their subdisciplines, genomic, proteomic, and metabolomic toxicology) will help to overcome such limitations. In particular, we discuss the advantages and disadvantages of mathematical frameworks that computationally represent biological systems. Finally, we discuss the nascent discipline of synthetic biology and highlight relevant toxicological centred applications of this technique, including improvements in personalised medicine. We conclude this review by presenting a number of opportunities and challenges that could shape the future of these rapidly evolving disciplines.
Citation
Mc Auley, M. T., Choi, H., Mooney, K., Paul, E., & Miller, V. M. (2015). Systems biology and synthetic biology: A new epoch for toxicology research. Advances in Toxicology, 2015, article number 575403. https://doi.org/10.1155/2015/575403
Publisher
Hindawi
Journal
Advances in Toxicology
Research Unit
DOI
10.1155/2015/575403
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PubMed Central ID
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Article
Language
en
Description
Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2356-6906
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Veronica M. Miller would like to acknowledge funding from Alexander and Bo McInnis and the Autism Research Institute for her toxicological studies and support.