Loading...
The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
Valpione, Sara Mundra, Piyushkumar A. Galvani, Elena Campana, Luca G.; orcid: 0000-0002-8466-8459 Lorigan, Paul; orcid: 0000-0002-8875-2164 De Rosa, Francesco; orcid: 0000-0003-0511-1298 Gupta, Avinash Weightman, John Mills, Sarah Dhomen, Nathalie
Valpione, Sara
Mundra, Piyushkumar A.
Galvani, Elena
Campana, Luca G.; orcid: 0000-0002-8466-8459
Lorigan, Paul; orcid: 0000-0002-8875-2164
De Rosa, Francesco; orcid: 0000-0003-0511-1298
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Publication Date
2021-07-02
Submitted Date
2020-07-30
Collections
Other Titles
Abstract
Abstract: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
Citation
Nature Communications, volume 12, issue 1, page 4098
Publisher
Nature Publishing Group UK
Journal
Research Unit
DOI
PubMed ID
PubMed Central ID
Type
article
Language
Description
From Springer Nature via Jisc Publications Router
History: received 2020-07-30, accepted 2021-06-09, registration 2021-06-16, pub-electronic 2021-07-02, online 2021-07-02, collection 2021-12
Publication status: Published
Funder: Harry J. Lloyd Charitable Trust; doi: https://doi.org/10.13039/100005976; Grant(s): Career Development Award
Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289; Grant(s): A27412, A22902
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440; Grant(s): 100282/Z/12/Z
History: received 2020-07-30, accepted 2021-06-09, registration 2021-06-16, pub-electronic 2021-07-02, online 2021-07-02, collection 2021-12
Publication status: Published
Funder: Harry J. Lloyd Charitable Trust; doi: https://doi.org/10.13039/100005976; Grant(s): Career Development Award
Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289; Grant(s): A27412, A22902
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440; Grant(s): 100282/Z/12/Z